When I first learnt the ropes of the jQuery framework and marvelled at the new possibilities it offered to me back in 2010, I couldn't imagine a day when it would become redundant. Since then it has been a staple to pretty much every website I've worked on, whether as a direct dependency or as an indirect dependency from another library or framework I've used.
jQuery: The student becomes the master, then the student again...
Hang on, did someone say Bootstrap?
This year we're expecting to be welcoming a jQuery-less Bootstrap 5 into the world. For many developers this is a key framework and certainly one of the big boys. The actions of one framework/library might not seem like the end of jQuery, but this feels like the beginning of what will likely become a trend with many other popular jQuery based frameworks and libraries too. Especially those who have the developer resource available for this kind of transition.
It may yet still be some time until we see a jQuery free WordPress system, but I can easily conceive the idea of a jQuery free Umbraco system this year at the earliest. We are a performance conscious development agency and dropping a 30kb~ dependency is a saving that would boost our page load times enough to have us more than a little interested.